Follow airport exit signs.  Follow signs for I-678 North (Van Wyck Expressway).
Take I-678 north for approximately 6 miles.  Bear left when road splits and follow
signs for the Grand Central Parkway West/LaGuardia Airport/Triboro Bridge. 
Take GCP westbound for approximately 1 mile and bear to the right for the Long Island Expressway (I-495) westbound exit ramp.  Take the Long Island Expressway westbound to the Queens Midtown Tunnel and follow the signs “Uptown” when exiting the tunnel.  Take 37th Street across town (westbound) until you reach 8th Avenue.  Make a right onto 8th Avenue.  Continue up 8th Avenue until you reach Columbus Circle.  Bear right around the circle to reach Broadway on the opposite side of the circle. Continue north up Broadway and make a left on 63rd Street.  The Empire Hotel will be on the left side between Broadway and Columbus Avenues. 

Follow airport exit signs for Grand Central Parkway Westbound Manhattan.   Take the Grand Central Parkway approximately 1 mile to the Brooklyn Queens Expressway Exit.
Ramp will take you southbound on the Brooklyn Queens Expressway.  Take BQE for
Approximately 4 miles and follow the signs for the Long Island Expressway/Queens Midtown Tunnel.  Take the Long Island Expressway westbound to the Queens Midtown Tunnel and follow the signs “Uptown” when exiting the tunnel.  Take 37th Street across town (westbound) until you reach 8th Avenue.  Make a right onto 8th Avenue.  Continue up 8th Avenue until you reach Columbus Circle.  Bear right around the circle to reach Broadway on the opposite side of the circle. Continue north up Broadway and make a left on 63rd Street.  The Empire Hotel will be on the left side between Broadway and Columbus Avenues.